- Original Article
- Serum methotrexate level is inversely related to the outcome of osteosarcoma patients
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Jun Ah Lee, Min Suk Kim, Jin Kyung Lee, Dong Ho Kim, Young Joon Hong, Won Seok Song, Wan Hyeong Cho, Soo-Yong Lee, Jung Sub Lim, Kyung Duk Park, Dae-Geun Jeon
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Clin Exp Pediatr. 2009;52(5):581-587. Published online May 15, 2009
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Purpose : To evaluate the correlation between serum methotrexate (MTX) peak levels and clinical outcome of osteosarcoma, as well as to determine the correlation of these levels with the histologic response and event-free survival (EFS).
Methods : To maintain the homogeneity of the study population, we selected 52 patients with localized extremity osteosarcoma who had received two cycles of neoadjuvant... |
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